SYRE Insider Trading

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About

Insider Ownership Percentage: 6.20%

Insider Buying (Last 12 Months): $0.00

Insider Selling (Last 12 Months): $10,929.00

Spyre Therapeutics Insider Trading History Chart

Spyre Therapeutics Share Price & Price History

^$14.77

▼ -0.25 (-1.66%)

As of 04/30/2025 02:13 PM ET

Days: 30 | 90 | 365

Spyre Therapeutics Insider Trading History

Transaction Date	Insider Name	Title	Buy/Sell	Number of Shares	Average Share Price	Total Transaction	Shares Held After Transaction	Details
10/25/2024	Jeffrey W. Albers	Director	Sell	300	$36.43	$10,929.00	34,060

SEC Filings (Institutional Ownership Changes) for Spyre Therapeutics (NASDAQ:SYRE)

80.39% of Spyre Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

Spyre Therapeutics Institutional Trading History

Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
4/29/2025	Bank of New York Mellon Corp	114,240	$1.84M	0.0%	+10.2%	0.190%
4/8/2025	Rhumbline Advisers	56,023	$0.90M	0.0%	-2.8%	0.093%
4/7/2025	GAMMA Investing LLC	4,356	$70K	0.0%	N/A	0.007%
3/24/2025	Wellington Management Group LLP	1,604,508	$37.35M	0.0%	+6.5%	2.663%
3/18/2025	California State Teachers Retirement System	32,598	$0.76M	0.0%	+32.1%	0.054%
2/28/2025	Universal Beteiligungs und Servicegesellschaft mbH	122,153	$2.84M	0.0%	N/A	0.238%
2/19/2025	GF Fund Management CO. LTD.	1,232	$29K	0.0%	N/A	0.002%
2/17/2025	UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	48,981	$1.14M	0.0%	+85.2%	0.095%
2/17/2025	Voloridge Investment Management LLC	115,470	$2.69M	0.0%	-26.2%	0.225%
2/17/2025	Woodline Partners LP	352,680	$8.21M	0.1%	+33.5%	0.686%
2/17/2025	Squarepoint Ops LLC	15,231	$0.36M	0.0%	+79.7%	0.030%
2/17/2025	RTW Investments LP	3,621,996	$84.32M	1.3%	+11.2%	7.043%
2/17/2025	Rafferty Asset Management LLC	76,740	$1.79M	0.0%	+8.7%	0.149%
2/17/2025	Polar Capital Holdings Plc	750,000	$17.46M	0.1%	+50.0%	1.458%
2/17/2025	ProShare Advisors LLC	12,531	$0.29M	0.0%	N/A	0.024%
2/17/2025	Prosight Management LP	80,000	$1.86M	0.5%	N/A	0.156%
2/17/2025	Paradigm Biocapital Advisors LP	1,527,205	$35.55M	1.2%	+20.5%	2.969%
2/17/2025	Millennium Management LLC	167,804	$3.91M	0.0%	N/A	0.326%
2/17/2025	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	22,741	$0.53M	0.0%	+4.2%	0.044%
2/17/2025	Janus Henderson Group PLC	1,456,740	$33.93M	0.0%	+30.0%	2.832%
2/17/2025	Jefferies Financial Group Inc.	1,216,954	$28.33M	0.2%	+167.6%	2.366%
2/17/2025	Deutsche Bank AG	31,418	$0.73M	0.0%	+46.1%	0.061%
2/17/2025	Deerfield Management Company L.P. Series C	450,000	$10.48M	0.2%	N/A	0.875%
2/17/2025	Driehaus Capital Management LLC	2,803,655	$65.27M	0.5%	+308.1%	5.451%
2/17/2025	Deep Track Capital LP	219,015	$5.10M	0.2%	-78.1%	0.426%
2/17/2025	Braidwell LP	2,578,404	$60.03M	1.8%	+17.7%	5.013%
2/17/2025	Brevan Howard Capital Management LP	16,899	$0.39M	0.0%	N/A	0.033%
2/17/2025	Blackstone Inc.	449,201	$10.46M	0.0%	+53.3%	0.873%
2/17/2025	Bank of America Corp DE	7,142	$0.17M	0.0%	-97.2%	0.014%
2/17/2025	BNP Paribas Financial Markets	18,784	$0.44M	0.0%	N/A	0.037%
2/14/2025	Boxer Capital Management LLC	466,680	$10.86M	0.9%	N/A	0.907%
2/14/2025	Soros Fund Management LLC	250,000	$5.82M	0.1%	+72.4%	0.486%
2/14/2025	Emerald Mutual Fund Advisers Trust	386,384	$9M	0.5%	+52.4%	0.751%
2/14/2025	Northern Trust Corp	348,983	$8.12M	0.0%	+11.0%	0.679%
2/14/2025	The Manufacturers Life Insurance Company	52,762	$1.23M	0.0%	+21.4%	0.103%
2/14/2025	Aquatic Capital Management LLC	11,767	$0.27M	0.0%	N/A	0.023%
2/14/2025	Boothbay Fund Management LLC	85,618	$1.99M	0.1%	-6.7%	0.166%
2/14/2025	Voya Investment Management LLC	10,495	$0.24M	0.0%	-7.5%	0.020%
2/14/2025	Adage Capital Partners GP L.L.C.	1,030,000	$23.98M	0.0%	-2.4%	2.003%
2/14/2025	Price T Rowe Associates Inc. MD	506,450	$11.79M	0.0%	+18.0%	0.985%
2/14/2025	B Group Inc.	50,000	$1.16M	0.7%	N/A	0.097%
2/14/2025	Tower Research Capital LLC TRC	8,574	$0.20M	0.0%	+1,548.8%	0.017%
2/14/2025	Teachers Retirement System of The State of Kentucky	25,799	$0.60M	0.0%	+22.0%	0.050%
2/14/2025	MetLife Investment Management LLC	21,382	$0.50M	0.0%	+6.2%	0.042%
2/14/2025	Capital World Investors	378,573	$8.81M	0.0%	N/A	0.736%
2/14/2025	First Trust Advisors LP	23,550	$0.55M	0.0%	N/A	0.046%
2/13/2025	Affinity Asset Advisors LLC	824,328	$19.19M	2.6%	+65.4%	1.603%
2/13/2025	Barclays PLC	123,071	$2.87M	0.0%	+16.7%	0.239%
2/13/2025	F M Investments LLC	48,806	$1.14M	0.0%	N/A	0.095%
2/13/2025	Legal & General Group Plc	37,490	$0.87M	0.0%	+14.8%	0.073%
2/13/2025	Invesco Ltd.	19,663	$0.46M	0.0%	-85.7%	0.038%
2/13/2025	FMR LLC	8,801,266	$204.89M	0.0%	+15.4%	17.113%
2/13/2025	Wells Fargo & Company MN	24,718	$0.58M	0.0%	+38.8%	0.048%
2/12/2025	ExodusPoint Capital Management LP	16,691	$0.39M	0.0%	+71.5%	0.032%
2/12/2025	Cinctive Capital Management LP	19,567	$0.46M	0.0%	-68.1%	0.038%
2/12/2025	Huntington National Bank	1,470	$34K	0.0%	N/A	0.003%
2/12/2025	Geode Capital Management LLC	966,129	$22.50M	0.0%	+8.4%	1.879%
2/12/2025	Wellington Management Group LLP	1,604,508	$37.35M	0.0%	+6.5%	3.120%
2/12/2025	Schroder Investment Management Group	113,620	$2.56M	0.0%	N/A	0.221%
2/12/2025	Pictet Asset Management Holding SA	1,092,124	$25.43M	0.0%	+32.3%	2.124%
2/12/2025	JPMorgan Chase & Co.	35,248	$0.82M	0.0%	+19.6%	0.069%
2/11/2025	EFG Asset Management North America Corp.	82,818	$1.93M	0.3%	+58.6%	0.161%
2/11/2025	Corebridge Financial Inc.	17,213	$0.40M	0.0%	-7.0%	0.033%
2/11/2025	Emerald Advisers LLC	546,791	$12.73M	0.5%	+86.9%	1.063%
2/11/2025	Vanguard Group Inc.	2,846,473	$66.27M	0.0%	+13.1%	5.535%
2/11/2025	KLP Kapitalforvaltning AS	7,800	$0.18M	0.0%	N/A	0.015%
2/11/2025	Teacher Retirement System of Texas	10,383	$0.24M	0.0%	N/A	0.020%
2/10/2025	Natixis Advisors LLC	17,300	$0.40M	0.0%	N/A	0.034%
2/10/2025	Swiss National Bank	68,600	$1.60M	0.0%	+38.3%	0.133%
2/7/2025	AlphaQuest LLC	2,198	$51K	0.0%	-61.1%	0.004%
2/7/2025	Candriam S.C.A.	247,591	$5.76M	0.0%	+135.8%	0.481%
2/6/2025	Arizona State Retirement System	10,115	$0.24M	0.0%	+38.4%	0.020%
2/6/2025	Victory Capital Management Inc.	268,076	$6.24M	0.0%	N/A	0.521%
2/6/2025	Charles Schwab Investment Management Inc.	379,650	$8.84M	0.0%	+13.9%	0.738%
2/6/2025	NBW Capital LLC	19,430	$0.45M	0.1%	-27.8%	0.038%
2/4/2025	Bank of New York Mellon Corp	103,688	$2.41M	0.0%	-1.1%	0.202%
1/30/2025	Rhumbline Advisers	57,657	$1.34M	0.0%	+6.9%	0.112%
1/27/2025	Mirae Asset Global Investments Co. Ltd.	1,955	$46K	0.0%	N/A	0.004%
1/24/2025	China Universal Asset Management Co. Ltd.	12,440	$0.29M	0.0%	N/A	0.024%
1/14/2025	Assenagon Asset Management S.A.	22,652	$0.53M	0.0%	-98.0%	0.044%
12/26/2024	JPMorgan Chase & Co.	29,473	$0.87M	0.0%	+29.4%	0.057%
11/27/2024	Franklin Resources Inc.	760,666	$23.32M	0.0%	+2.5%	1.479%
11/18/2024	Teachers Retirement System of The State of Kentucky	21,154	$0.62M	0.0%	N/A	0.041%
11/16/2024	Geode Capital Management LLC	891,048	$26.21M	0.0%	+16.4%	1.733%
11/15/2024	Barclays PLC	105,467	$3.10M	0.0%	+64.7%	0.205%
11/15/2024	Jane Street Group LLC	20,641	$0.61M	0.0%	+78.7%	0.040%
11/15/2024	Wellington Management Group LLP	1,507,200	$44.33M	0.0%	+89.4%	2.931%
11/15/2024	State Street Corp	1,541,555	$45.34M	0.0%	+9.4%	2.997%
11/15/2024	Ikarian Capital LLC	302,247	$8.89M	1.2%	N/A	0.588%
11/15/2024	Janus Henderson Group PLC	1,120,531	$32.92M	0.0%	+66.3%	2.179%
11/15/2024	HighVista Strategies LLC	105,351	$3.10M	1.1%	-7.2%	0.205%
11/15/2024	Cinctive Capital Management LP	61,256	$1.80M	0.1%	N/A	0.119%
11/14/2024	Braidwell LP	2,189,836	$64.40M	1.8%	-12.9%	4.258%
11/14/2024	Walleye Capital LLC	243,372	$7.16M	0.0%	+61.4%	0.473%
11/14/2024	UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	26,441	$0.78M	0.0%	-12.2%	0.051%
11/14/2024	MetLife Investment Management LLC	20,132	$0.59M	0.0%	+129.1%	0.039%
11/13/2024	FMR LLC	7,623,881	$224.22M	0.0%	+1.5%	14.824%
11/13/2024	The Manufacturers Life Insurance Company	43,460	$1.28M	0.0%	+15.0%	0.085%
11/12/2024	Charles Schwab Investment Management Inc.	333,275	$9.80M	0.0%	+239.4%	0.655%
11/9/2024	Intech Investment Management LLC	8,371	$0.25M	0.0%	N/A	0.016%

Data available starting January 2016

See Full Table

Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.

Today's Range

Now: $14.77

$14.64

$15.15

50 Day Range

MA: $16.27

$11.80

$21.29

52 Week Range

Now: $14.77

$10.91

$40.49

Volume

119,062 shs

Average Volume

598,178 shs

Market Capitalization

$890.28 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

3.05

Who are the company insiders with the largest holdings of Spyre Therapeutics?: Spyre Therapeutics' top insider shareholders include:
Jeffrey W Albers (Director)
Learn More about top insider investors at Spyre Therapeutics.
Who are the major institutional investors of Spyre Therapeutics?: Spyre Therapeutics' top institutional shareholders include:
Bank of New York Mellon Corp — 0.19%
Rhumbline Advisers — 0.09%
GAMMA Investing LLC — 0.01%
Learn More about top institutional investors of Spyre Therapeutics stock.
Which institutional investors are selling Spyre Therapeutics stock?: In the last quarter, SYRE stock was sold by these institutional investors:
Rhumbline Advisers
Which institutional investors are buying Spyre Therapeutics stock?: In the last quarter, SYRE stock was bought by institutional investors including:
Bank of New York Mellon Corp
GAMMA Investing LLC