Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
11/16/2022	Alphabet Inc.	189,122	$0.25M	0.0%	N/A	0.627%
11/14/2022	PDT Partners LLC	45,948	$61K	0.0%	-78.3%	0.152%
11/9/2022	EPIQ Capital Group LLC	2,056,669	$2.74M	1.3%	-37.2%	6.821%
9/16/2022	Federated Hermes Inc.	528,564	$1.17M	0.0%	+27.8%	1.753%
8/12/2022	Strategic Blueprint LLC	13,800	$31K	0.0%	-47.5%	0.046%
8/8/2022	Walleye Capital LLC	75,694	$0.17M	0.0%	N/A	0.251%
5/12/2022	Capital Fund Management S.A.	68,956	$0.43M	0.0%	-63.4%	0.229%
4/29/2022	SG Americas Securities LLC	56,316	$0.35M	0.0%	N/A	0.187%
3/3/2022	Walleye Capital LLC	137,166	$1.73M	0.0%	N/A	0.459%
2/15/2022	Capital International Investors	1,461,827	$18.45M	0.0%	-50.9%	4.893%
2/15/2022	Capital World Investors	2,501,882	$31.57M	0.0%	-28.3%	8.374%
2/14/2022	PDT Partners LLC	82,315	$1.04M	0.1%	N/A	0.276%
2/14/2022	Virtus ETF Advisers LLC	14,471	$0.18M	0.1%	+223.4%	0.048%
2/14/2022	Squarepoint Ops LLC	144,974	$1.83M	0.0%	+1,486.5%	0.485%
2/14/2022	Point72 Hong Kong Ltd	3,803	$48K	0.0%	+281.1%	0.013%
2/14/2022	LMR Partners LLP	28,541	$0.36M	0.0%	N/A	0.096%
2/14/2022	GSA Capital Partners LLP	88,544	$1.12M	0.1%	+488.2%	0.296%
2/11/2022	Ensign Peak Advisors Inc	33,040	$0.42M	0.0%	N/A	0.111%
2/10/2022	Capital Fund Management S.A.	188,222	$2.38M	0.0%	N/A	0.630%
2/9/2022	BNP Paribas Arbitrage SA	179,613	$2.27M	0.0%	+4,905.9%	0.601%
2/9/2022	EPIQ Capital Group LLC	4,269,109	$53.88M	9.6%	+8.0%	14.288%
2/8/2022	Bank of America Corp DE	224,376	$2.83M	0.0%	-472.6%	0.751%
2/8/2022	Northern Trust Corp	193,561	$2.44M	0.0%	-3.6%	0.648%
1/28/2022	Allspring Global Investments Holdings LLC	7,171	$90K	0.0%	N/A	0.024%
1/24/2022	Strs Ohio	8,100	$0.10M	0.0%	+97.6%	0.027%
11/16/2021	Captrust Financial Advisors	4,634	$0.43M	0.0%	+1,783.7%	0.016%
11/16/2021	Intellectus Partners LLC	42,889	$3.93M	1.0%	+28.2%	0.144%
11/16/2021	Squarepoint Ops LLC	9,138	$0.84M	0.0%	N/A	0.031%
11/16/2021	Two Sigma Advisers LP	38,500	$3.53M	0.0%	+309.6%	0.129%
11/16/2021	Two Sigma Investments LP	73,075	$6.70M	0.0%	+102.2%	0.245%
11/16/2021	Voloridge Investment Management LLC	69,545	$6.37M	0.0%	+109.6%	0.233%
11/16/2021	Capital World Investors	3,486,995	$319.62M	0.1%	+4.8%	11.671%
11/15/2021	Point72 Hong Kong Ltd	998	$91K	0.0%	+326.5%	0.003%
11/15/2021	Cubist Systematic Strategies LLC	9,777	$0.90M	0.0%	+71.5%	0.033%
11/15/2021	California State Teachers Retirement System	24,107	$2.21M	0.0%	-12.4%	0.081%
11/15/2021	Tudor Investment Corp Et Al	3,205	$0.29M	0.0%	N/A	0.011%
11/15/2021	Marshall Wace LLP	60,701	$5.56M	0.0%	+57.0%	0.203%
11/15/2021	Gotham Asset Management LLC	3,659	$0.34M	0.0%	N/A	0.012%
11/15/2021	Cinctive Capital Management LP	6,000	$0.55M	0.0%	-25.0%	0.020%
11/15/2021	GSA Capital Partners LLP	15,053	$1.38M	0.1%	+13.2%	0.050%
11/12/2021	Trexquant Investment LP	4,195	$0.39M	0.0%	N/A	0.014%
11/12/2021	EPIQ Capital Group LLC	3,953,595	$362.39M	37.5%	+5.0%	13.232%
11/12/2021	The Manufacturers Life Insurance Company	78,246	$7.17M	0.0%	-29.9%	0.262%
11/12/2021	Credit Suisse AG	10,324	$0.95M	0.0%	+7.4%	0.035%
11/12/2021	Geode Capital Management LLC	329,847	$30.23M	0.0%	+9.3%	1.104%
11/12/2021	Bellwether Advisors LLC	6,934	$0.64M	0.2%	N/A	0.023%
11/12/2021	Hennion & Walsh Asset Management Inc.	89,419	$8.20M	0.4%	+9.4%	0.299%
11/10/2021	Citigroup Inc.	55,810	$5.12M	0.0%	-2.1%	0.187%
11/10/2021	Rafferty Asset Management LLC	26,905	$2.47M	0.0%	-25.3%	0.090%
11/10/2021	Creative Planning	2,510	$0.23M	0.0%	N/A	0.008%
11/10/2021	Robertson Stephens Wealth Management LLC	19,773	$1.81M	0.2%	-29.4%	0.066%
11/9/2021	Teacher Retirement System of Texas	2,609	$0.24M	0.0%	N/A	0.009%
11/9/2021	55I LLC	2,400	$0.22M	0.0%	N/A	0.008%
11/9/2021	Barclays PLC	8,253	$0.76M	0.0%	+205.4%	0.028%
11/9/2021	BlackRock Inc.	1,325,048	$121.46M	0.0%	+3.2%	4.435%
11/9/2021	Principal Financial Group Inc.	10,222	$0.94M	0.0%	+50.1%	0.034%
11/9/2021	TD Asset Management Inc.	5,200	$0.48M	0.0%	N/A	0.017%
11/8/2021	Meeder Asset Management Inc.	850	$79K	0.0%	N/A	0.003%
11/4/2021	Deutsche Bank AG	16,353	$1.50M	0.0%	+30.6%	0.055%
11/3/2021	Letko Brosseau & Associates Inc.	5,473	$0.50M	0.0%	-42.2%	0.018%
11/2/2021	New York State Common Retirement Fund	14,394	$1.32M	0.0%	-16.5%	0.048%
11/1/2021	Cherry Creek Investment Advisors Inc.	8,873	$0.81M	0.5%	-39.8%	0.030%
11/1/2021	Cedar Brook Financial Partners LLC	2,218	$0.20M	0.1%	N/A	0.007%
11/1/2021	SG Americas Securities LLC	9,730	$0.89M	0.0%	N/A	0.033%
10/29/2021	Amalgamated Bank	3,549	$0.33M	0.0%	N/A	0.012%
10/26/2021	Cohen Lawrence B	11,126	$1.02M	0.5%	+23.7%	0.037%
10/25/2021	Foster Dykema Cabot & Co. Inc. MA	3,061	$0.28M	0.0%	N/A	0.010%
10/22/2021	Strs Ohio	4,100	$0.38M	0.0%	N/A	0.014%
10/20/2021	AJ Wealth Strategies LLC	4,520	$0.41M	0.0%	N/A	0.015%
10/18/2021	Nisa Investment Advisors LLC	300	$27K	0.0%	N/A	0.001%
10/14/2021	Hamilton Lane Advisors LLC	12,612	$1.16M	0.2%	+40.4%	0.042%
10/12/2021	17 Capital Partners LLC	3,675	$0.34M	0.3%	N/A	0.012%
9/17/2021	Virtu Financial LLC	5,397	$0.29M	0.0%	N/A	0.018%
9/3/2021	Parametric Portfolio Associates LLC	7,236	$0.38M	0.0%	+3.8%	0.024%
8/25/2021	Marshall Wace LLP	38,651	$2.05M	0.0%	N/A	0.130%
8/25/2021	Marshall Wace North America L.P.	55,709	$2.95M	0.0%	N/A	0.188%
8/18/2021	Ikarian Capital LLC	20,533	$1.09M	0.1%	N/A	0.069%
8/17/2021	Robertson Stephens Wealth Management LLC	28,010	$1.48M	0.2%	+17.4%	0.094%
8/17/2021	Metropolitan Life Insurance Co NY	5,245	$0.28M	0.0%	+104,800.0%	0.018%
8/17/2021	Price T Rowe Associates Inc. MD	39,400	$2.09M	0.0%	N/A	0.133%
8/16/2021	UBS Asset Management Americas Inc.	13,077	$0.69M	0.0%	+83.5%	0.044%
8/16/2021	Cubist Systematic Strategies LLC	5,702	$0.30M	0.0%	-2.8%	0.019%
8/16/2021	California State Teachers Retirement System	27,514	$1.46M	0.0%	+15.7%	0.093%
8/16/2021	Capital International Investors	2,736,669	$145.04M	0.0%	+11.2%	9.219%
8/16/2021	Royal Bank of Canada	6,365	$0.34M	0.0%	+583.7%	0.021%
8/16/2021	Credit Suisse AG	9,609	$0.51M	0.0%	-15.4%	0.032%
8/16/2021	Schonfeld Strategic Advisors LLC	7,800	$0.41M	0.0%	N/A	0.026%
8/16/2021	Pinz Capital Management LP	2,300	$0.12M	0.0%	N/A	0.008%
8/16/2021	Charles Schwab Investment Management Inc.	105,847	$5.61M	0.0%	+10.4%	0.357%
8/16/2021	State Street Corp	962,815	$51.03M	0.0%	-9.7%	3.243%
8/16/2021	Nuveen Asset Management LLC	97,352	$5.16M	0.0%	+38.6%	0.328%
8/16/2021	Cinctive Capital Management LP	8,000	$0.42M	0.0%	N/A	0.027%
8/16/2021	Federated Hermes Inc.	31,596	$1.68M	0.0%	N/A	0.106%
8/16/2021	Marshall Wace LLP	38,651	$2.05M	0.0%	N/A	0.130%
8/13/2021	Harvard Management Co. Inc.	2,937	$0.16M	0.0%	N/A	0.010%
8/13/2021	Northern Trust Corp	205,114	$10.87M	0.0%	+21.0%	0.691%
8/13/2021	Intellectus Partners LLC	33,450	$1.77M	0.4%	+51.7%	0.113%
8/13/2021	Cherry Creek Investment Advisors Inc.	14,730	$0.78M	0.5%	N/A	0.050%
8/13/2021	Nachman Norwood & Parrott Inc	5,514	$0.29M	0.0%	N/A	0.019%
8/13/2021	Blueshift Asset Management LLC	4,387	$0.23M	0.0%	N/A	0.015%

Data available starting January 2016

Cortexyme, Inc., a clinical stage biopharmaceutical company, focuses on developing therapeutics for Alzheimer's and other degenerative diseases. Its lead drug candidate is atuzaginstat (COR388), an orally administered brain-penetrating small molecule gingipain inhibitor, which is in Phase II/III clinical trial for use in patients with mild to moderate Alzheimer's disease, as well as for the treatment of oral squamous cell carcinoma, periodontitis, and coronavirus infection. The company was incorporated in 2012 and is headquartered in South San Francisco, California.

Today's Range

Now: $1.78

$1.74

$1.85

50 Day Range

MA: $1.61

$0.69

$2.16

52 Week Range

Now: $1.78

$1.78

$40.66

Volume

106,261 shs

Average Volume

620,672 shs

Market Capitalization

$53.67 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.4

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