Reporting Date	Hedge Fund	Shares Held	Market Value	% of Portfolio	Quarterly Change in Shares	Ownership in Company
5/1/2023	Virtu Financial LLC	280,430	$35K	0.0%	N/A	0.414%
2/9/2023	HBK Sorce Advisory LLC	52,000	$53K	0.0%	+100.0%	0.077%
11/14/2022	RA Capital Management L.P.	1,954,698	$0.72M	0.0%	N/A	2.887%
10/27/2022	Assenagon Asset Management S.A.	75,283	$28K	0.0%	-35.6%	0.111%
7/27/2022	Assenagon Asset Management S.A.	116,814	$65K	0.0%	+70.9%	0.172%
5/16/2022	LGL Partners LLC	19,200	$44K	0.0%	N/A	0.028%
5/16/2022	Frazier Life Sciences Management L.P.	1,883,244	$4.28M	0.4%	N/A	2.781%
5/4/2022	Victory Capital Management Inc.	140,360	$0.32M	0.0%	N/A	0.207%
4/25/2022	Assenagon Asset Management S.A.	68,338	$0.16M	0.0%	N/A	0.101%
2/14/2022	Point72 Asset Management L.P.	167,604	$0.45M	0.0%	N/A	0.248%
2/14/2022	Blair William & Co. IL	19,177	$51K	0.0%	N/A	0.028%
2/8/2022	Raymond James & Associates	90,380	$0.24M	0.0%	-20.3%	0.133%
1/31/2022	Commonwealth Equity Services LLC	11,100	$29K	0.0%	N/A	0.016%
1/18/2022	Lindbrook Capital LLC	20,000	$53K	0.0%	N/A	0.030%
11/16/2021	Squarepoint Ops LLC	15,015	$35K	0.0%	-55.9%	0.022%
11/16/2021	Two Sigma Advisers LP	247,500	$0.58M	0.0%	-36.3%	0.365%
11/16/2021	Millennium Management LLC	1,041,392	$2.44M	0.0%	-7.7%	1.538%
11/12/2021	Renaissance Technologies LLC	475,942	$1.11M	0.0%	-23.0%	0.703%
11/2/2021	Raymond James & Associates	113,330	$0.27M	0.0%	-11.3%	0.167%
10/19/2021	Assenagon Asset Management S.A.	12,930	$30K	0.0%	-56.2%	0.019%
9/17/2021	Virtu Financial LLC	80,202	$0.23M	0.0%	N/A	0.118%
8/25/2021	Marshall Wace LLP	19,776	$56K	0.0%	N/A	0.029%
8/17/2021	Millennium Management LLC	1,127,712	$3.19M	0.0%	-20.3%	1.665%
8/17/2021	Price T Rowe Associates Inc. MD	41,121	$0.12M	0.0%	N/A	0.061%
8/17/2021	Boothbay Fund Management LLC	13,887	$39K	0.0%	N/A	0.021%
8/16/2021	Squarepoint Ops LLC	34,061	$96K	0.0%	-44.1%	0.050%
8/16/2021	Cubist Systematic Strategies LLC	29,939	$85K	0.0%	N/A	0.044%
8/16/2021	Alberta Investment Management Corp	550,000	$1.56M	0.0%	N/A	0.812%
8/16/2021	AWH Capital L.P.	675,000	$1.91M	1.7%	+2.9%	0.997%
8/16/2021	Charles Schwab Investment Management Inc.	17,590	$50K	0.0%	-80.2%	0.026%
8/16/2021	State Street Corp	129,502	$0.37M	0.0%	-73.2%	0.191%
8/16/2021	Tibra Equities Europe Ltd	115,200	$0.33M	0.1%	N/A	0.170%
8/16/2021	Goldman Sachs Group Inc.	56,728	$0.16M	0.0%	+42.2%	0.084%
8/16/2021	Marshall Wace LLP	19,776	$56K	0.0%	N/A	0.029%
8/13/2021	Renaissance Technologies LLC	618,457	$1.75M	0.0%	-17.3%	0.913%
8/13/2021	Northern Trust Corp	189,342	$0.54M	0.0%	-58.7%	0.280%
8/13/2021	DCF Advisers LLC	114,000	$0.32M	0.1%	-12.3%	0.167%
8/13/2021	Adams Street Partners LLC	5,395,996	$15.27M	3.2%	+1.7%	7.915%
8/13/2021	Geode Capital Management LLC	370,132	$1.05M	0.0%	-38.2%	0.543%
8/13/2021	Vanguard Group Inc.	1,808,522	$5.12M	0.0%	+6.2%	2.653%
8/12/2021	XTX Topco Ltd	18,640	$53K	0.0%	N/A	0.027%
8/12/2021	Dimensional Fund Advisors LP	151,411	$0.43M	0.0%	-6.5%	0.222%
8/12/2021	Ergoteles LLC	148,100	$0.42M	0.0%	N/A	0.217%
8/11/2021	Bank of New York Mellon Corp	96,630	$0.27M	0.0%	-47.7%	0.142%
8/11/2021	BlackRock Inc.	1,350,565	$3.82M	0.0%	-56.0%	1.981%
8/11/2021	Deutsche Bank AG	41,699	$0.12M	0.0%	-36.1%	0.061%
8/11/2021	Frazier Management LLC	1,883,244	$5.33M	0.5%	-41.0%	2.762%
7/22/2021	Meridian Wealth Management LLC	192,000	$0.54M	0.1%	+45.5%	0.282%
5/19/2021	Squarepoint Ops LLC	60,978	$0.18M	0.0%	+308.8%	0.089%
5/18/2021	Millennium Management LLC	1,414,065	$4.24M	0.0%	-23.7%	2.074%
5/18/2021	Morgan Stanley	371,361	$1.11M	0.0%	-39.6%	0.545%
5/18/2021	Jane Street Group LLC	10,761	$32K	0.0%	N/A	0.016%
5/17/2021	Ameriprise Financial Inc.	15,300	$46K	0.0%	N/A	0.023%
5/17/2021	Nuveen Asset Management LLC	187,156	$0.56M	0.0%	+17.0%	0.279%
5/17/2021	Goldman Sachs Group Inc.	39,896	$0.12M	0.0%	-14.0%	0.060%
5/14/2021	Dimensional Fund Advisors LP	161,951	$0.49M	0.0%	+7.3%	0.242%
5/13/2021	Barclays PLC	28,638	$86K	0.0%	+87.8%	0.043%
5/13/2021	Renaissance Technologies LLC	748,198	$2.25M	0.0%	-21.3%	1.117%
5/12/2021	Northern Trust Corp	458,732	$1.38M	0.0%	+26.1%	0.685%
5/12/2021	Geode Capital Management LLC	599,275	$1.80M	0.0%	+21.6%	0.895%
5/12/2021	JPMorgan Chase & Co.	211,639	$0.64M	0.0%	-34.1%	0.316%
5/10/2021	GSA Capital Partners LLP	27,126	$81K	0.0%	-72.2%	0.041%
5/7/2021	BlackRock Inc.	3,071,468	$9.21M	0.0%	+9.2%	4.586%
5/7/2021	BNP Paribas Arbitrage SA	13,915	$42K	0.0%	+131.2%	0.021%
4/26/2021	Assenagon Asset Management S.A.	419,281	$1.26M	0.0%	-6.5%	0.626%
4/12/2021	Calamos Wealth Management LLC	10,000	$30K	0.0%	N/A	0.015%
3/26/2021	Susquehanna International Group LLP	54,852	$0.19M	0.0%	N/A	0.087%
3/8/2021	Dimensional Fund Advisors LP	150,976	$0.52M	0.0%	+20.8%	0.239%
2/25/2021	Dimensional Fund Advisors LP	150,976	$0.52M	0.0%	+20.8%	0.239%
2/25/2021	Hsbc Holdings PLC	41,751	$0.14M	0.0%	-12.6%	0.066%
2/19/2021	JPMorgan Chase & Co.	321,137	$1.11M	0.0%	+54.2%	0.508%
2/16/2021	Silverarc Capital Management LLC	107,536	$0.37M	0.2%	N/A	0.170%
2/16/2021	Squarepoint Ops LLC	14,916	$52K	0.0%	-79.5%	0.024%
2/16/2021	Charles Schwab Investment Management Inc.	88,906	$0.31M	0.0%	+26.1%	0.141%
2/13/2021	American International Group Inc.	19,833	$69K	0.0%	+30.9%	0.031%
2/12/2021	DCF Advisers LLC	131,000	$0.45M	0.2%	+42.7%	0.207%
2/12/2021	Laurion Capital Management LP	286,426	$0.99M	0.0%	N/A	0.453%
2/12/2021	Credit Suisse AG	11,233	$39K	0.0%	N/A	0.018%
2/11/2021	Northern Trust Corp	363,917	$1.26M	0.0%	+26.6%	0.575%
2/11/2021	Barclays PLC	15,252	$52K	0.0%	-86.0%	0.024%
2/11/2021	Artal Group S.A.	2,502,035	$8.66M	0.2%	+66.6%	3.955%
2/10/2021	Rhumbline Advisers	34,171	$0.12M	0.0%	+43.7%	0.054%
2/10/2021	HighPoint Advisor Group LLC	11,791	$48K	0.0%	N/A	0.019%
2/10/2021	Renaissance Technologies LLC	950,150	$3.29M	0.0%	+23.8%	1.502%
2/9/2021	Wells Fargo & Company MN	50,976	$0.18M	0.0%	+20.0%	0.081%
2/9/2021	Bank of New York Mellon Corp	181,834	$0.63M	0.0%	+72.7%	0.287%
2/8/2021	New York State Common Retirement Fund	15,500	$54K	0.0%	+5,066.7%	0.025%
2/5/2021	BlackRock Inc.	2,812,060	$9.73M	0.0%	+12.0%	4.445%
2/4/2021	GSA Capital Partners LLP	97,631	$0.34M	0.1%	N/A	0.154%
2/1/2021	Assenagon Asset Management S.A.	448,219	$1.55M	0.0%	+560.6%	0.709%
1/19/2021	Meridian Wealth Management LLC	132,000	$0.46M	0.1%	+120.0%	0.209%
11/12/2020	JPMorgan Chase & Co.	208,288	$0.69M	0.0%	+33.6%	0.444%
11/10/2020	State Street Corp	311,000	$1.05M	0.0%	+14.9%	0.662%

Data available starting January 2016

Aptinyx Inc., a clinical-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of novel, proprietary, and synthetic small molecules for the treatment of brain and nervous system disorders. Its lead product candidate NYX-783, an N-methyl-D-aspartate receptors (NMDAr) modulator that is in Phase I clinical trial to treat opioid use disorder, or OUD; and in preclinical trial for the treatment of alcohol use disorder, or AUD. The company has a research collaboration agreement with Allergan plc. Aptinyx Inc. was incorporated in 2015 and is headquartered in Evanston, Illinois.

Today's Range

Now: $0.10

$0.09

$0.10

50 Day Range

MA: $0.08

$0.06

$0.10

52 Week Range

Now: $0.10

$0.01

$0.72

Volume

231,100 shs

Average Volume

1,317,051 shs

Market Capitalization

N/A

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.27

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